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February 2, 2025
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June 1, 2025
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June 30, 2025
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Abstract

Regenerative therapies for myocardial infarction require viable vascularized cardiac tissues. We report the development of 3D bioprinted cardiac patches using patient-derived induced pluripotent stem cells (iPSCs) and endothelial progenitor cells. Bioprinted tissues exhibited spontaneous contraction, vascular network formation, and appropriate electromechanical coupling. In a rat myocardial infarction model, transplanted patches improved cardiac function and reduced scar size significantly. This work paves the way for personalized cardiac regenerative therapies.

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3D bioprinting cardiac tissue engineering vascularization iPSCs myocardial infarction regenerative medicine

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Copyright (c) 2025 Mohammed R. Abd Ali, Mohammed Malih Radhi, Hussein Assak Al-Hachami, Nada Nada Khazal K. Hindi, Rusull Hamza K. AL-Jubori, Wamidh H. Talib (Author)

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Mohammed R. Abd Ali (2025) “Development of 3D Bioprinted Vascularized Cardiac Tissues Using Patient-Derived Stem Cells: A Preclinical Study”, Journal of Biomedicine and Biochemistry, 4(2), pp. 57–74. doi:10.57238/jbb.2025.7432.1140.
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Mohammed R. Abd Ali (2025) “Development of 3D Bioprinted Vascularized Cardiac Tissues Using Patient-Derived Stem Cells: A Preclinical Study”, Journal of Biomedicine and Biochemistry, 4(2), pp. 57–74. doi:10.57238/jbb.2025.7432.1140.
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