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Submitted
March 9, 2026
Accepted
June 1, 2026
Published
June 12, 2026
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Abstract

Background and Aim: Preterm birth affects over 15 million infants annually worldwide, with cervical insufficiency being a major contributing factor. This study evaluates CRP and WBC levels in pregnant women undergoing cervical cerclage to predict Early Preterm Birth (EPTB) risk.


Methods: A prospective observational study conducted at Bint al-Huda Hospital, Thi-Qar, Iraq, from December 2023 to December 2024. Fifty-four pregnant women with singleton pregnancies and cervical insufficiency (cervical length <25 mm) were enrolled. CRP and WBC levels were measured pre-cerclage and on days 1 and 2 post-cerclage, with follow-up until delivery.


Results: Mean participant age was 30.2 years. Cervical length improved from 20.6 mm pre-cerclage to 23.8 mm post-cerclage. Mean gestational age at cerclage was 20.6 weeks, with delivery occurring at a mean of 35.3 weeks. Only 18.5% delivered before 34 weeks, while 81.5% delivered at or beyond 34 weeks. Elevated pre-cerclage CRP and WBC levels were significantly associated with increased EPTB risk. Post-cerclage monitoring identified persistent inflammation correlating with adverse outcomes.


Conclusions: CRP and WBC are reliable biomarkers for predicting EPTB in women undergoing cervical cerclage. Elevated pre-cerclage levels indicate higher risk, necessitating close monitoring and early intervention. Post-cerclage trends provide critical insights into inflammatory responses, enabling targeted management to improve maternal and neonatal outcomes. Further research is recommended to refine predictive models and explore therapeutic strategies.

Keywords

CRP Cervical Preterm Labour WBC cervical cerclage

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Copyright (c) 2026 Nawar Hasan Jaaz, Alaa Hussein Ali Nasser (Author)

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Nawar Hasan Jaaz and Alaa Hussein Ali Nasser (2026) “C-Reactive Protein and White Blood Cell Count at Pre / Post Cervical Cerclage Predict Early Preterm Labour”, Journal of Biomedicine and Biochemistry, 5(2), pp. 84–92. doi:10.57238/jbb.2026.7432.1174.
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How to Cite

Nawar Hasan Jaaz and Alaa Hussein Ali Nasser (2026) “C-Reactive Protein and White Blood Cell Count at Pre / Post Cervical Cerclage Predict Early Preterm Labour”, Journal of Biomedicine and Biochemistry, 5(2), pp. 84–92. doi:10.57238/jbb.2026.7432.1174.
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