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Abstract
This research includes the synthesis of some new heterocyclic derivatives (pyridine derivatives), firstly reaction of (2-amino-5-chloropyridine, 2-amino-4- methyl pyridine) With aromatics benzaldehydes (p-bromobenzaldehyde, dimethyl amino benzaldehyde , p-chlorobenzaldehyde, Salicylic aldehyde, p- amino benzaldehyde) to form different derivatives of schiff bases, secondly reaction of Schiff base derivatives with thioglycolic acid to form thiazolidinone derivatives, all resulting compounds characterized by FT-IR.
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- Abdul-Rida, N. A., & Gareeb, Z. M.. Preparation and Characterization Biaryl aromatic compounds of the pyrimidine derivative by a Suzuki Coupling reaction and study their anti-cancer effect. In Journal of Physics: Conference Series (Vol. 1664, No. 1, p. 012089). (2020, November). https://doi:10.1088/1742-6596/1664/1/012089
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- Abdullah, A. D. & Saleem, N. H. Preparation and identification of some new thiazolidine -4-one compounds from Schiff base derivatives. Journal of Education and Science, 29(3), 142-0 2020. http://dx.doi.org/10.33899/edusj.2020.126881.1061
- Hoshino, Y., Mukai, A., Yazawa, K., Uno, J., Ishikawa, J., Ando, A., ... & Mikami, Y. Transvalencin A, a thiazolidine zinc complex antibiotic produced by a clinical isolate of Nocardia transvalensis I. Taxonomy, fermentation, isolation and biological activities. The Journal of antibiotics, 57(12), 797-802(2004). https://doi.org/10.7164/antibiotics.57.797
- Synthesis, D. DRUG SYNTHESIS SYNTHESIS AND In Vitro ANTIMICROBIAL STUDY OF SCHIFF BASE AND THIAZOLIDINONE OF 1-CYCLOPROPYL-6-FLUORO-7- [ 4- ( 2 , 3-. 67, 45–53 (2010).
- Isloor, A. M., Sunil, D. & Shetty, P. CHEMISTRY Synthesis , characterization , anticancer , and antioxidant activity of some new thiazolidin-4-ones in MCF-7 cells. 758–767 (2013) https://doi:10.1007/s00044-012-0071-5 .
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- Mahmood, Z. M. & Ahmad, A. K. Synthesis of Some Heterocyclic Compounds Derived From 2-Amino Benzothiazole. 2020, Journal of Education and Science, 29(4), 193-205. http://dx.doi.org/10.33899/edusj.1999.163310
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- Rabello, M. M. et al. Structural Investigation of Anti- Trypanosoma cruzi 2 ‑ Iminothiazolidin-4-ones Allows the Identi fi cation of Agents with E ffi cacy in Infected Mice. (2013). https://doi.org/10.1021/jm301518v
- Hosseinimehr, S. J., Shafiee, A., Mozdarani, H., Akhlagpour, S. & Froughizadeh, M. Radioprotective Effects of 2-Imino-3- [( chromone-2-yl ) carbonyl ] thiazolidines against γ -Irradiation in Mice. 300, 293–300 (2002). https://doi.org/10.1269/jrr.43.293
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- Nikalje, A. P. G., Ansari, A., Bari, S. & Ugale, V. Synthesis, Biological Activity, and Docking Study of Novel Isatin Coupled Thiazolidin-4-one Derivatives as Anticonvulsants. (2015) https://doi:10.1002/ardp.201500020
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- Samadhiya, P., Sharma, R., Srivastava, S. K. & Srivastava, S. D. SYNTHESIS OF 4-THIAZOLIDINE DERIVATIVES OF 6-NITROINDAZOLE : PHARMACEUTICAL IMPORTANCE. 1, (2012). http://dx.doi.org/10.4067/S0717-97072012000100018
- Murugesan, V. et al. Bioorganic & Medicinal Chemistry Lead optimization at C-2 and N-3 positions of thiazolidin-4-ones as HIV-1 non-nucleoside reverse transcriptase inhibitors. Bioorg. Med. Chem. 19, 6919–6926 (2011). https://doi.org/10.1016/j.bmc.2011.09.018
- Viswas, R. S., Haq, W., Smilkstein, M. J., Health, O. & Srivastava, K. Synthesis and Antimalarial Activity of Novel Side Chain Modified Antimalarial Agents Derived from 4Aminoquinoline. (2008) https://doi:10.1021/jm061002i
- Kim, H. & Leroith, D. Thiazolidinediones improve insulin sensitivity in adipose tissue and reduce the hyperlipidaemia without affecting the hyperglycaemia in a transgenic model of type 2 diabetes. 2215–2225 (2004) https://doi.org/10.1007/s00125-004-1581-6
- Javed, M. et al. Synthesis , molecular docking and anti-diabetic evaluation of 2 , 4- thiazolidinedione based amide derivatives Bioorganic Chemistry Synthesis , molecular docking and anti-diabetic evaluation of 2 , 4-thiazolidinedione based amide derivatives. Bioorg. Chem. 73, 24–36 (2017). https://doi.org/10.1016/j.bioorg.2017.05.007
- Hamad, B. K., & Ahamed, M. R. Synthesis of new compounds with seven rings (oxazepine) through the ring closure of Schiff bases with study of biological activity. Eurasian Chem. Commun, 4, 1306-1317. (2022). DOI: 10.22034/ecc.2022.332079.1343
- Salam, A. & Shakir, M. SYNTHESIS AND CHARACTERIZATION OF SOME 4-SUBSTITUTED THIAZOLIDINONE DERIVATIVES. Eur. Chem. Bull, 6(5), 201-205. (2017).
References
Abdul-Rida, N. A., & Gareeb, Z. M.. Preparation and Characterization Biaryl aromatic compounds of the pyrimidine derivative by a Suzuki Coupling reaction and study their anti-cancer effect. In Journal of Physics: Conference Series (Vol. 1664, No. 1, p. 012089). (2020, November). https://doi:10.1088/1742-6596/1664/1/012089
Abdelhalim, M. M., El-saidi, M. M. T., Rabie, S. T. & Elmegeed, G. A. Synthesis of novel steroidal heterocyclic derivatives as antibacterial agents Synthesis of novel steroidal heterocyclic derivatives as antibacterial agents. (2007). https://doi:10.1016/j.steroids.2007.01.003 .
Dalal, M. J., & Mekky, A. H. Synthesis, Characterization and Antioxidant Evaluation of Some Tetrazole Derivatives. Indonesian Journal of chemistry, 22(6), 1596-1604(2022). https://doi.org/10.22146/ijc.74912
Küçükgüzel SG, Küçükgüzel I, Tatar E, Rollas S, Sahin F, Güllüce M, De Clercq E, Kabasakal L. Synthesis of some novel heterocyclic compounds derived from diflunisal hydrazide as potential anti-infective and anti-inflammatory agents. Eur J Med Chem. 2007 Jul;42(7):893-901. Epub 2007 Feb 25. PMID: 17418454. https://org.doi/10.1016/j.ejmech.2006.12.038.
Abdullah, A. D. & Saleem, N. H. Preparation and identification of some new thiazolidine -4-one compounds from Schiff base derivatives. Journal of Education and Science, 29(3), 142-0 2020. http://dx.doi.org/10.33899/edusj.2020.126881.1061
Hoshino, Y., Mukai, A., Yazawa, K., Uno, J., Ishikawa, J., Ando, A., ... & Mikami, Y. Transvalencin A, a thiazolidine zinc complex antibiotic produced by a clinical isolate of Nocardia transvalensis I. Taxonomy, fermentation, isolation and biological activities. The Journal of antibiotics, 57(12), 797-802(2004). https://doi.org/10.7164/antibiotics.57.797
Synthesis, D. DRUG SYNTHESIS SYNTHESIS AND In Vitro ANTIMICROBIAL STUDY OF SCHIFF BASE AND THIAZOLIDINONE OF 1-CYCLOPROPYL-6-FLUORO-7- [ 4- ( 2 , 3-. 67, 45–53 (2010).
Isloor, A. M., Sunil, D. & Shetty, P. CHEMISTRY Synthesis , characterization , anticancer , and antioxidant activity of some new thiazolidin-4-ones in MCF-7 cells. 758–767 (2013) https://doi:10.1007/s00044-012-0071-5 .
Li, Y. et al. Bioorganic & Medicinal Chemistry Letters Synthesis and biological evaluation of 1 , 3-diaryl pyrazole derivatives as potential antibacterial and anti-inflammatory agents. 25, 5052–5057 (2015). https://doi.org/10.1016/j.bmcl.2015.10.028
Mahmood, Z. M. & Ahmad, A. K. Synthesis of Some Heterocyclic Compounds Derived From 2-Amino Benzothiazole. 2020, Journal of Education and Science, 29(4), 193-205. http://dx.doi.org/10.33899/edusj.1999.163310
Gan, M. W. Ă., Stan, C. Ă. T. Ă. L. D., Pânzariu, A., Reanu, A. J. I. T. Ă. & Profire, L. Ţ. A. NEW THIAZOLIDINE-4-ONES OF FERULIC ACID WITH ANTIOXIDANT POTENTIAL. 63, 4–8 (2015).
Rabello, M. M. et al. Structural Investigation of Anti- Trypanosoma cruzi 2 ‑ Iminothiazolidin-4-ones Allows the Identi fi cation of Agents with E ffi cacy in Infected Mice. (2013). https://doi.org/10.1021/jm301518v
Hosseinimehr, S. J., Shafiee, A., Mozdarani, H., Akhlagpour, S. & Froughizadeh, M. Radioprotective Effects of 2-Imino-3- [( chromone-2-yl ) carbonyl ] thiazolidines against γ -Irradiation in Mice. 300, 293–300 (2002). https://doi.org/10.1269/jrr.43.293
Thomas, B. & Harindran, J. Design , Synthesis and Evaluation of Antitubercular Activity of Mannich Bases of Isoniazid-Containing Thiazolidin-4-one Rings. (2016).
Nikalje, A. P. G., Ansari, A., Bari, S. & Ugale, V. Synthesis, Biological Activity, and Docking Study of Novel Isatin Coupled Thiazolidin-4-one Derivatives as Anticonvulsants. (2015) https://doi:10.1002/ardp.201500020
Patel, J. B. & Desai, V. A. Archive of SID I nternational J ournal of I ndustrial C hemistry Synthesis of Some New Thiazolidinones Derived from 1-p-Tolylethanone and Their Antibacterial and Antifungal Activities Archive of SID. 2, 45–51 (2011).
Samadhiya, P., Sharma, R., Srivastava, S. K. & Srivastava, S. D. SYNTHESIS OF 4-THIAZOLIDINE DERIVATIVES OF 6-NITROINDAZOLE : PHARMACEUTICAL IMPORTANCE. 1, (2012). http://dx.doi.org/10.4067/S0717-97072012000100018
Murugesan, V. et al. Bioorganic & Medicinal Chemistry Lead optimization at C-2 and N-3 positions of thiazolidin-4-ones as HIV-1 non-nucleoside reverse transcriptase inhibitors. Bioorg. Med. Chem. 19, 6919–6926 (2011). https://doi.org/10.1016/j.bmc.2011.09.018
Viswas, R. S., Haq, W., Smilkstein, M. J., Health, O. & Srivastava, K. Synthesis and Antimalarial Activity of Novel Side Chain Modified Antimalarial Agents Derived from 4Aminoquinoline. (2008) https://doi:10.1021/jm061002i
Kim, H. & Leroith, D. Thiazolidinediones improve insulin sensitivity in adipose tissue and reduce the hyperlipidaemia without affecting the hyperglycaemia in a transgenic model of type 2 diabetes. 2215–2225 (2004) https://doi.org/10.1007/s00125-004-1581-6
Javed, M. et al. Synthesis , molecular docking and anti-diabetic evaluation of 2 , 4- thiazolidinedione based amide derivatives Bioorganic Chemistry Synthesis , molecular docking and anti-diabetic evaluation of 2 , 4-thiazolidinedione based amide derivatives. Bioorg. Chem. 73, 24–36 (2017). https://doi.org/10.1016/j.bioorg.2017.05.007
Hamad, B. K., & Ahamed, M. R. Synthesis of new compounds with seven rings (oxazepine) through the ring closure of Schiff bases with study of biological activity. Eurasian Chem. Commun, 4, 1306-1317. (2022). DOI: 10.22034/ecc.2022.332079.1343
Salam, A. & Shakir, M. SYNTHESIS AND CHARACTERIZATION OF SOME 4-SUBSTITUTED THIAZOLIDINONE DERIVATIVES. Eur. Chem. Bull, 6(5), 201-205. (2017).