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January 20, 2025
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March 5, 2025
Published
March 25, 2025
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Abstract





The present review is to evaluate the current state of knowledge in regard to health effects of endocrine disrupting chemicals (EDCs) in humans, with a special reference to recently published research. The primary target audi- ence aside from scientists will be policymakers, public health professionals, and health practitioners who need an up-to-date broad understanding of the issue in the form of a concise compilation of peer-reviewed literature. The main goal serves to synthesize recent research findings regarding the most important toxicological mechanisms associated with EDCs and recent advancements in understanding their health effects. A major emphasis is placed on research that has been published in peer-reviewed journals over the past years, with less attention being given to systematic reviews. Infor- mation found in the literature bears a description of current knowledge of the human health effects of EDCs, focusing on recent scientific publications. Greater familiarity with the complexities of EDC exposure routes, mech- anisms, and the large variety of chemicals that have endocrine-disrupting properties is also aimed. By detailing the state of research, it is hoped that the review may help clarify the complexities for regulatory authorities, enabling for more accurate decision-making with regards to management of EDCs. Additionally, this contribution is intended to advance the cur- rent public health and regulatory debate about EDCs, by highlighting the challenges faced in regulation and proposing potential directions for their effective management.





Keywords

Endocrine Regulatory Challenges Toxicological Mechanisms

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Copyright (c) 2025 Mona M. Youssef, Aya M. Helal, Yasser I. Khedr (Author)

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Mona M. Youssef, Aya M. Helal, Yasser I. Khedr. Endocrine Disrupting Chemicals and Human Health: A Review of Toxicological Mechanisms and Regulatory Challenges. JBB [Internet]. 2025 Mar. 25 [cited 2025 May 21];4(1):14-26. Available from: https://biomedbiochem.nabea.pub/biomedbiochem/article/view/86
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Mona M. Youssef, Aya M. Helal, Yasser I. Khedr. Endocrine Disrupting Chemicals and Human Health: A Review of Toxicological Mechanisms and Regulatory Challenges. JBB [Internet]. 2025 Mar. 25 [cited 2025 May 21];4(1):14-26. Available from: https://biomedbiochem.nabea.pub/biomedbiochem/article/view/86
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